Current Advances in Nanomaterial-associated Micro and Nano-devices for SARS-CoV-2 Detection

COVID-19 spread rapidly around the world in 18 months, with various forms of variants caused by severe acute respiratory syndrome (SARS-CoV). This has put pressure on the world community and created an urgent need for understanding its early occurrence through rapid, simple, cheap, and yet highly accurate diagnosis. The most widely adopted method as of today is the real-time reverse-transcriptase polymerase chain reaction. This test has shown the potential for rapid testing, but unfortunately, the test is not rapid and, in some cases, displays false negatives or false positives. The nanomaterials play an important role in creating highly sensitive systems, and have been thought to significantly improve the performance of the SARSCoV- 2 protocols. Several biosensors based on micro-and nano-sensors for SARS-CoV-2 detection have been reported, and they employ multi-dimensional hybrids on sensing surfaces with devices having different sizes and geometries. Zero-to-three-dimension nanomaterial hybrids on sensing surfaces, including nanofilm hybrids for SARS-CoV-2 detection, were employed with unprecedented sensitivity and accuracy. Furthermore, the sensors were nanofluidic and mediated high-performance SARS-CoV-2 detection. This breakthrough has brought the possibility of making a biosystem on a chip (Bio-SoC) for rapid, cheap, and point-of-care detection. This review summarises various advancements in nanomaterial-associated nanodevices and metasurface devices for detecting SARS-CoV-2.

Nanosensors: Recent Perspectives on Attainments and Future Promise of Downstream Applications

Nano Sensors are sensing devices with a dimension of less than or equal to 100nm. They are incredibly tiny devices that transform physical, chemical, or biological substances into detectable signals. Because of this device's capacity to detect physical and chemical changes, nanotechnology has emerged as a technology of choice in a variety of industries. The device provides efficient and cost-effective methods for detecting and measuring chemical and physical characteristics. This overview discusses the status of Nano Sensors, as well as their accomplishments and potential applications toward downstream targets in medical, security, agriculture as well in Covid-19 detection. The paper provides a summary and critical analysis of various architectures (structures) employed in the development and use of Nano Sensors. Surface engineering is used to generate diverse chemistries for both general and specialised purposes. We derived fresh findings from available data on the mechanism, prospective development of various structures, approaches, and applications, and highlighted the contrasts and similarities in their characteristics and working processes. The review further summarized ability and future expected of this sensor in dealing with the various challenges where different nano sensors, types, fabrication techniques and applications with highlighted novelties of these techniques and applications are presented.